PGD Method for Gender (Sex) Selection

PGD/PGS can be used to detect which embryos are XX or XY. PGD allows analysis of the genetic makeup of the early embryos. Then, the desired embryos can be placed into the female’s uterus to achieve pregnancy.

PGD is performed as part of an in vitro fertilization (IVF) cycle. In order for PGD to be performed, couples must undergo IVF to allow for the formation of early embryos in the laboratory. When embryos are three days old (typically containing 6-8 cells), PGD is performed by inserting a tiny needle into each embryo and removing 1 or 2 cells (called blastomeres). To check the removed blastomeres, various techniques of gene amplification and chromosomal analysis are next applied in order to analyze removed blastomeres for their genetic make-up. Embryos determined to be abnormal are discarded, and only the normal embryos of the desired gender are transferred into the uterus within approximately 24 hours of the procedure.

Occasionally, the use of PGD for gender selection may not work because there may not be any embryos of the desired gender produced. This risk is higher when the woman suffers from premature ovarian aging (POA) or has other conditions that reduce the number of oocytes (eggs) that her ovaries can produce. However, in general, IVF with PGD is the most successful and accurate way to perform gender selection. Its only limitation is the fertility potential of the couple attempting pregnancy. Accuracy of PGD for gender selection is almost 100%, barring technical errors.

Numerous studies have documented the safety of PGD. Overall, PGD is ideal for couples who have several children of one gender and are interested in sex selection for their next child.

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